Cantilever-based microsystem for contact and non-contact deposition of picoliter biological samples
Résumé
This paper describes a cantilever-based microsystem that permits the deposition of picoliter biological samples using a contact or non-contact method. Arrays of silicon-based cantilevers have been used to produce DNA microarrays. An electrowetting-on-dielectric (EWOD) principle is applied for the loading of the liquid by controlling surface tension. Deposition is achieved by direct contact between cantilevers and the surface by capillary transport. A non-contact deposition method has also been developed. It consists in an electric-field applied between the cantilevers and a conductive surface. The results obtained demonstrate that our system meets the need for producing high-density DNA, protein and cell chips.
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