NOVEOS and ImmunoCAP Have Similar Performances for Diagnosing Food Allergies - Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250
Article Dans Une Revue Journal of Allergy and Clinical Immunology: In Practice Année : 2024

NOVEOS and ImmunoCAP Have Similar Performances for Diagnosing Food Allergies

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Background: The clinical significance of newly available platforms for specific IgE measurement must be evaluated. However, data are lacking for NOVEOS (Hycor), especially for food allergens. Objective: We compared the technical and clinical performance of two platforms (ImmunoCAP and NOVEOS) to measure specific IgE to 10 food allergens. Methods: Sera from 289 clinically characterized patients were tested for IgE specific for six food allergen extracts (egg white, cow's milk, peanut, hazelnut, fish, and shrimp) and four molecular allergens (Gal d 1, Bos d 8, Ara h 2, and Cor a 14). Specific IgE measurements were carried out using ImmunoCAP and NOVEOS methods. Food allergy diagnoses were established according to international guidelines. Results: A strong correlation (ρ > 0.9) was present between the two platforms whereas specific IgE concentrations measured with NOVEOS were consistently lower (mean, -15%) than with ImmunoCAP. NOVEOS and ImmunoCAP provided similar overall odds ratios and relative risks for food allergy diagnosis with both allergen extracts and molecular allergens. When all 10 allergens were considered, NOVEOS provided better receiver operating characteristic curves (P = .04). Finally, we found that the most discordant results were observed with hazelnut and peanut extracts and were related to cross-reactive carbohydrate determinants for these two with ImmunoCAP. Conclusions: Specific IgE determination by either ImmunoCAP or NOVEOS (odds ratios of allergy, 25.1 or 33.0, respectively) is highly informative regarding the risk of allergy in the selected population. The NOVEOS platform presents the advantage of being less affected by unwanted reactivity owing to carbohydrate determinant-specific IgE while requiring a 10-fold lower test sample volume.
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hal-04679999 , version 1 (28-08-2024)

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Benjamin Trouche-Estival, Joana Vitte, Audrey Martin-Blondel, Marine Michelet, Vianney Gruzelle, et al.. NOVEOS and ImmunoCAP Have Similar Performances for Diagnosing Food Allergies. Journal of Allergy and Clinical Immunology: In Practice, 2024, 12 (6), pp.1605-1613.e5. ⟨10.1016/j.jaip.2024.02.037⟩. ⟨hal-04679999⟩
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